darrenG10
Well-known member
When it comes to the destruction, degeneration, and healing of connective tissue there are MANY factors that must be addressed in order to slow, halt, or reverse problems.
As I have said before there are three main types of insult to connective tissue.
1. Acute injury from overloading, overstretching, such as repetitive strain. When it comes to this kind healing can be helped by MINOR intervention. RICE, Rest, ice, compression, elevation, then heat/blood flow stimulation will help the healing.
2. Chronic non-autoimmune related damage/degeneration This category can include degeneration that is both from repeated local events and sytemic insult like
a. repetitive strain syndrome where the the inflammation healing process is blocked and the cell/ECM balance is upset. PROLOtherapy is useful in this non-inflammatory often hyper-cellular condition.
b. chronic over use destroying cartilage in joints from too much mechanical load and not enough healing time. Obesity and over training fall into this category.
3. systemic inflammatory cell signalling leading to tissue degradation through normal function. No major "Acute injury" and no major "over use". A poor diet, nutrient issues, and other things can lead to this. For this conditon NATURAL anti-inflammatory suplements and laser/led therapy is VERY useful.
PLEASE READ
"The irreversible destruction of the cartilage, tendon, and bone that comprise synovial joints is the hallmark of both rheumatoid arthritis (RA) and osteoarthritis (OA). While cartilage is made up of proteoglycans and type II collagen, tendon and bone are composed primarily of type I collagen. RA is an autoimmune disease afflicting numerous joints throughout the body; in contrast, OA develops in a small number of joints, usually resulting from chronic overuse or injury. In both diseases, inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) stimulate the production of matrix metalloproteinases (MMPs), enzymes that can degrade all components of the extracellular matrix."
Matrix metalloproteinases: role in arthritis. - PubMed - NCBI
For more tendon, tumor, disc related studies on MMP and how it relates to combating degradation please see these threads.
http://www.professionalmuscle.com/f...ssible-alternative-spinal-fusion-surgery.html
http://www.professionalmuscle.com/forums/professional-muscle-forum/123406-tumor-found-liver-4.html
Getting back to this topic.
"The collagenases, MMP-1 and MMP-13, have predominant roles in RA and OA because they are rate limiting in the process of collagen degradation. MMP-1 is produced primarily by the synovial cells that line the joints, and MMP-13 is a product of the chondrocytes that reside in the cartilage. In addition to collagen, MMP-13 also degrades the proteoglycan molecule, aggrecan, giving it a dual role in matrix destruction."
Matrix metalloproteinases: role in arthritis. - PubMed - NCBI
SO if the source is acute injury, repetitive strain, systemic inflammation, the rate of degradation is limited or advanced by MMPs
Since controlling MMP's is needed by lowering their expression AND by increasing their limiters tIMPs we must look at HOW THIS IS DONE regardless of the mechanisms by which they are altered (RA, OA, Diet, etc).
things that hurt (raise MMP, or lower tIMP, or cause inflammation)
1. bad diet, digestion issues
2. auto-immune issues
3. Many OTC/script NSAIDs
Things that help
1. Many natural supplements
2. Laser/LED therapy
3. Micro current (frequency specific Micro current)
Continued next post
F
Registered
For the sake of brevity I will post one therapy/,modaltiy, "crazy" "alternative" quakery" "lunatic" idea at a time.
photbiostimulation
Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation.
"The objective was to evaluate the effect of low-level laser therapy (LLLT) operating at 50 mW and 100 mW on joint inflammation in rats induced by papain, through histopathological analysis, differential counts of inflammatory cells (macrophages and neutrophils), as well as gene expression of interleukin 1-beta and 6 (IL-1β and IL-6), and protein expression of tumor necrosis factor alpha (TNFα).
RESULT Laser treatment with 50 mW was more efficient than 100 mW in reducing cellular inflammation, and decreased the expression of IL-1β and IL-6. However, the 100 mW treatment led to a higher reduction of TNFα compared with the 50 mW treatment."
Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation. - PubMed - NCBI
As you can see this is just ONE study that show Photons are good for healing.
SINCE we are trying to BALANCE MMP, tIMP, it follows that
1. Laser/LED lowers TNFa and other inflammatory markers
2. Lowering TNFa, etc, will lower MMPs
3. Lower MMPs will most likely slow, stop, or reveres tissue degradation SINCE MMPs are the "rate limiting factor"
ALso LASER/LED is proven to increase cell proliferation, fibroblast activity, and ECM deposition. NOT only that but it causes a "Good" ROS/MMP reaction whereby BENEFICIAL tissue remodeling can take place.
Low-Level Laser Irradiation Stimulates Tenocyte Migration with Up-Regulation of Dynamin II Expression
"Low-level laser therapy (LLLT) is commonly used to treat sports-related tendinopathy or tendon injury. Tendon healing requires tenocyte migration to the repair site, followed by proliferation and synthesis of the extracellular matrix. This study was designed to determine the effect of laser on tenocyte migration.
In conclusion, low-level laser irradiation stimulates tenocyte migration in a process that is mediated by up-regulation of dynamin 2, which can be suppressed by dynasore.
Low-Level Laser Irradiation Stimulates Tenocyte Migration with Up-Regulation of Dynamin II Expression
Biostimulatory effect of low-level laser therapy on keratinocytes in vitro.
"Real-time polymerase chain reaction (qPCR) revealed that LLLT also promoted an increase of type I collagen (Col-I) and vascular endothelial growth factor (VEGF) gene expression, especially for 1.5 J/cm2, but no change on fibroblast growth factor-2 (FGF-2) expression was observed. LLLT at energy doses ranging from 0.5 to 3 J/cm2 promoted the most significant biostimulatory effects on cultured keratinocytes."
Biostimulatory effect of low-level laser therapy on keratinocytes in vitro. - PubMed - NCBI
Bottom line is LASER does
1. Lowers inflammation
2. lowers MMP and degredation
3. Stimulates cell migration (essential for healing injury)
4. Stimulates fibroblast ECM deposition
5. Increase NO, blood flow, micro-circulation, and nerve function.
As I have said before there are three main types of insult to connective tissue.
1. Acute injury from overloading, overstretching, such as repetitive strain. When it comes to this kind healing can be helped by MINOR intervention. RICE, Rest, ice, compression, elevation, then heat/blood flow stimulation will help the healing.
2. Chronic non-autoimmune related damage/degeneration This category can include degeneration that is both from repeated local events and sytemic insult like
a. repetitive strain syndrome where the the inflammation healing process is blocked and the cell/ECM balance is upset. PROLOtherapy is useful in this non-inflammatory often hyper-cellular condition.
b. chronic over use destroying cartilage in joints from too much mechanical load and not enough healing time. Obesity and over training fall into this category.
3. systemic inflammatory cell signalling leading to tissue degradation through normal function. No major "Acute injury" and no major "over use". A poor diet, nutrient issues, and other things can lead to this. For this conditon NATURAL anti-inflammatory suplements and laser/led therapy is VERY useful.
PLEASE READ
"The irreversible destruction of the cartilage, tendon, and bone that comprise synovial joints is the hallmark of both rheumatoid arthritis (RA) and osteoarthritis (OA). While cartilage is made up of proteoglycans and type II collagen, tendon and bone are composed primarily of type I collagen. RA is an autoimmune disease afflicting numerous joints throughout the body; in contrast, OA develops in a small number of joints, usually resulting from chronic overuse or injury. In both diseases, inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) stimulate the production of matrix metalloproteinases (MMPs), enzymes that can degrade all components of the extracellular matrix."
Matrix metalloproteinases: role in arthritis. - PubMed - NCBI
For more tendon, tumor, disc related studies on MMP and how it relates to combating degradation please see these threads.
http://www.professionalmuscle.com/f...ssible-alternative-spinal-fusion-surgery.html
http://www.professionalmuscle.com/forums/professional-muscle-forum/123406-tumor-found-liver-4.html
Getting back to this topic.
"The collagenases, MMP-1 and MMP-13, have predominant roles in RA and OA because they are rate limiting in the process of collagen degradation. MMP-1 is produced primarily by the synovial cells that line the joints, and MMP-13 is a product of the chondrocytes that reside in the cartilage. In addition to collagen, MMP-13 also degrades the proteoglycan molecule, aggrecan, giving it a dual role in matrix destruction."
Matrix metalloproteinases: role in arthritis. - PubMed - NCBI
SO if the source is acute injury, repetitive strain, systemic inflammation, the rate of degradation is limited or advanced by MMPs
Since controlling MMP's is needed by lowering their expression AND by increasing their limiters tIMPs we must look at HOW THIS IS DONE regardless of the mechanisms by which they are altered (RA, OA, Diet, etc).
things that hurt (raise MMP, or lower tIMP, or cause inflammation)
1. bad diet, digestion issues
2. auto-immune issues
3. Many OTC/script NSAIDs
Things that help
1. Many natural supplements
2. Laser/LED therapy
3. Micro current (frequency specific Micro current)
Continued next post
F
Floxedone
New member
Registered
For the sake of brevity I will post one therapy/,modaltiy, "crazy" "alternative" quakery" "lunatic" idea at a time.
photbiostimulation
Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation.
"The objective was to evaluate the effect of low-level laser therapy (LLLT) operating at 50 mW and 100 mW on joint inflammation in rats induced by papain, through histopathological analysis, differential counts of inflammatory cells (macrophages and neutrophils), as well as gene expression of interleukin 1-beta and 6 (IL-1β and IL-6), and protein expression of tumor necrosis factor alpha (TNFα).
RESULT Laser treatment with 50 mW was more efficient than 100 mW in reducing cellular inflammation, and decreased the expression of IL-1β and IL-6. However, the 100 mW treatment led to a higher reduction of TNFα compared with the 50 mW treatment."
Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation. - PubMed - NCBI
As you can see this is just ONE study that show Photons are good for healing.
SINCE we are trying to BALANCE MMP, tIMP, it follows that
1. Laser/LED lowers TNFa and other inflammatory markers
2. Lowering TNFa, etc, will lower MMPs
3. Lower MMPs will most likely slow, stop, or reveres tissue degradation SINCE MMPs are the "rate limiting factor"
ALso LASER/LED is proven to increase cell proliferation, fibroblast activity, and ECM deposition. NOT only that but it causes a "Good" ROS/MMP reaction whereby BENEFICIAL tissue remodeling can take place.
Low-Level Laser Irradiation Stimulates Tenocyte Migration with Up-Regulation of Dynamin II Expression
"Low-level laser therapy (LLLT) is commonly used to treat sports-related tendinopathy or tendon injury. Tendon healing requires tenocyte migration to the repair site, followed by proliferation and synthesis of the extracellular matrix. This study was designed to determine the effect of laser on tenocyte migration.
In conclusion, low-level laser irradiation stimulates tenocyte migration in a process that is mediated by up-regulation of dynamin 2, which can be suppressed by dynasore.
Low-Level Laser Irradiation Stimulates Tenocyte Migration with Up-Regulation of Dynamin II Expression
Biostimulatory effect of low-level laser therapy on keratinocytes in vitro.
"Real-time polymerase chain reaction (qPCR) revealed that LLLT also promoted an increase of type I collagen (Col-I) and vascular endothelial growth factor (VEGF) gene expression, especially for 1.5 J/cm2, but no change on fibroblast growth factor-2 (FGF-2) expression was observed. LLLT at energy doses ranging from 0.5 to 3 J/cm2 promoted the most significant biostimulatory effects on cultured keratinocytes."
Biostimulatory effect of low-level laser therapy on keratinocytes in vitro. - PubMed - NCBI
Bottom line is LASER does
1. Lowers inflammation
2. lowers MMP and degredation
3. Stimulates cell migration (essential for healing injury)
4. Stimulates fibroblast ECM deposition
5. Increase NO, blood flow, micro-circulation, and nerve function.